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Increased glucose-dependent insulinotropic polypeptide (GIP) secretion in acromegaly
M Peracchi1, S Porretti, C Gebbia
1Department of Medical Sciences, Ospedale Maggiore IRCCS, University of Milan, 20122, Milan, Italy. maddalena.peracchi@unimi.it
European Journal of Endocrinology
|June 21, 2001
Summary
Patients with acromegaly show elevated fasting and postprandial glucose-dependent insulinotropic polypeptide (GIP) levels. This GIP hypersecretion may contribute to the hyperinsulinemia characteristic of acromegaly.
Area of Science:
- Endocrinology
- Metabolic Disorders
Background:
- Acromegaly is linked to hyperinsulinemia, but underlying mechanisms are unclear.
- Inconsistent data exist regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in acromegaly-associated hyperinsulinemia.
Purpose of the Study:
- To investigate the fasting and postprandial patterns of plasma GIP and insulin in acromegalic patients.
- To determine if GIP hypersecretion contributes to hyperinsulinemia in acromegaly.
Main Methods:
- Studied 11 non-diabetic acromegalic patients and 11 healthy controls.
- Measured growth hormone (GH), GIP, and insulin levels in fasting and postprandial states (3 hours after a meal).
Main Results:
- Acromegalic patients exhibited significantly higher fasting and postprandial GIP levels compared to controls.
- Fasting and integrated GIP responses correlated with GH levels in acromegalic patients.
- Elevated GIP levels were independent of glucose tolerance, age, sex, and insulin levels.
Conclusions:
- Patients with acromegaly demonstrate abnormally high fasting and postprandial GIP levels.
- GIP hypersecretion is implicated in the pathogenesis of hyperinsulinemia in acromegaly.