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Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
Published on: June 21, 2016
[Assessment of aortic atherosclerosis with transesophageal echocardiography]
1Serviço de Cardiologia do Hospital Garcia de Orta, Almada. rafadame@mail.telepac.pt
Insights
Transesophageal echocardiography assessed thoracic aorta atherosis and sclerosis. Age correlated with atherosis, and blood pressure with sclerosis, but lipid levels did not significantly correlate with either aortic condition.
Area of Science:
- Cardiovascular Imaging
- Vascular Biology
- Diagnostic Medicine
Background:
- Atherosclerosis and aortic stiffness are key indicators of cardiovascular risk.
- Transesophageal echocardiography (TEE) offers a detailed view of the thoracic aorta.
- Understanding the determinants of aortic atherosis and sclerosis is crucial for risk stratification.
Purpose of the Study:
- To evaluate thoracic aorta atherosis (plaque burden) and sclerosis (stiffness) using TEE.
- To investigate the correlation between aortic plaque burden and stiffness with serum lipid levels.
- To identify key factors influencing aortic atherosis and sclerosis.
Main Methods:
- 29 patients underwent elective TEE to assess aortic diameter, plaque morphology, and location.
- Calculated stiffness coefficient and total atherosis index (TAI) based on TEE measurements.
- Analyzed correlations between TAI, stiffness coefficient, age, and serum lipid profiles.
Main Results:
- The descending aorta segments (25-40 cm from incisors) were best visualized.
- No significant correlation was found between lipid levels and TAI or stiffness coefficient.
- TAI showed a significant positive correlation with age (r=0.62, p<0.001).
- Stiffness coefficient showed a significant positive correlation with diastolic blood pressure (r=0.42, p<0.05).
Conclusions:
- Serum lipid levels were not a primary factor in thoracic aortic atherosclerosis in this patient group.
- Age is a significant determinant of aortic atherosis.
- Blood pressure is a significant determinant of aortic sclerosis.
Objective:
To image the thoracic aorta by transesophageal echocardiography (TEE) and study atherosis (morphology and extent of atheroma plaques) and sclerosis (stiffness) and secondarily correlate them with serum lipid levels (cholesterol, HDL, LDL and triglycerides).
Methods:
We studied 29 patients (pts) who underwent TEE electively (male 18 pts, age 57.8 +/- 14.6 years). The parameters evaluated were: the stiffness coefficient = ln (PAsist/PAdiast)/(Dsyst/Dmin), and the morphology, location and extent of atheroma plaques. The systolic distension (Dsyst) was the difference between the maximal and the minimal dimensions (Dmin) of the aortic diameter measured by M mode. The lesions were classified in 4 degrees (0-3): 0--normal intima, 1--intimal thickening, 2--atheroma, 3--complicated lesion. Five aortic segments were studied: arch, D1-D4 (descending aorta at 5 cm intervals from the first 25 cm distal of the incisors line). We calculated the individual score = 1 x theta 1/180 + 2 x theta 2/180 + 3 x theta 3/180, theta n represents the angles occupied by the lesions and n (1-3) the severity of atherosis of each lesion. The total atherosis index (TAI) was sigma scores/(n. degree of visualized segments).
Results:
The arch was not visualized in 3 pts, and the segment D4 was only visualized in 3 pts. TAI mean = 0.82 +/- 0.74, stiffness coefficient mean (SC) = 9.56 +/- 15.072. There were no significant correlations between the lipid levels and the TAI or SC. The only significant positive correlations were: TAI vs age (r = 0.62, p < 0.001) and SC and diastolic blood pressure (BP) (r = 0.42, p < 0.05).
Conclusions:
The best visualized segments belong to the descending aorta (25 to 40 cm from the incisors). In this group of patients the lipid levels did not seem to be a preponderant factor in aortic atherosclerosis. The most important factors were age for atherosis and BP for sclerosis.
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