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[Albinism: diagnosis by visual evoked potentials].
1Kantonsspital St. Gallen, Augenklinik, Rorschacherstrasse 95, CH-9007 St. Gallen. bela.torok@kssg.ch
Klinische Monatsblatter Fur Augenheilkunde
|June 22, 2001
Summary
Visual evoked potentials (VEP) reveal abnormal nerve fiber crossing in albinism. This VEP lateralization is a sensitive indicator for detecting ocular albinism.
Area of Science:
- Neuroscience
- Ophthalmology
- Genetics
Context:
- Albinism involves abnormal optic nerve innervation, leading to contralateral hemisphere dominance.
- Visual evoked potentials (VEP) can detect this unilateral visual cortex activation (lateralization).
Purpose:
- To investigate the detectability of VEP lateralization in patients with albinism using pattern onset stimulation.
- To assess if VEP lateralization is a sensitive diagnostic marker for albinism.
Summary:
- Multichannel pattern onset VEPs were recorded from 22 patients with albinism and 15 controls.
- VEP lateralization was consistently detected in albinism patients, but not in normal volunteers.
- Simulated nystagmus in controls did not induce VEP lateralization.
Impact:
- VEP lateralization is a reliable indicator of abnormal optic nerve crossing in oculocutaneous and ocular albinism.
- This method offers higher sensitivity for diagnosing ocular albinism compared to other clinical signs.