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Related Concept Videos

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Related Experiment Video

Updated: Jun 28, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Brain volume in autism.

A Y Hardan1, N J Minshew, M Mallikarjuhn

  • 1Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA. hardanay@msx.upmc.edu

Journal of Child Neurology
|June 22, 2001
PubMed
Summary
This summary is machine-generated.

Individuals with autism often show increased brain size. This study found significantly larger cerebral and third ventricle volumes in non-mentally retarded autistic individuals compared to controls, supporting existing research on brain volume differences in autism.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Medical Imaging

Background:

  • Autism is associated with varied cognitive abilities and observed brain size differences.
  • Previous research indicates larger brain volumes in some individuals with autism spectrum disorder (ASD).

Purpose of the Study:

  • To measure brain volumes in a specific group of autistic individuals without intellectual disability.
  • To investigate differences in specific brain structures between autistic and neurotypical subjects.

Main Methods:

  • Utilized magnetic resonance imaging (MRI) scans for 16 non-mentally retarded autistic individuals and 19 male controls.
  • Measured volumes of the third, fourth, and lateral ventricles, as well as intracranial and cerebral volumes.

Main Results:

  • Autistic subjects exhibited significantly greater mean cerebral and third ventricle volumes compared to controls, after adjusting for intracranial volume.
  • No other significant volumetric differences were detected between the groups.

Conclusions:

  • The findings align with prior studies reporting increased brain volume in autism.
  • Further longitudinal neuroimaging and neuropathologic studies are recommended to understand the causes of enlarged brain size in autism.