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Vancomycin-resistant enterococci: mechanisms and clinical observations

H S Gold1

  • 1Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. hogold@caregroup.harvard.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 22, 2001
PubMed

Insights

Enterococci bacteria are becoming resistant to antibiotics like vancomycin, making infections harder to treat. This review covers resistance mechanisms and their impact on patient care and infection control.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Enterococci are opportunistic pathogens.
  • Antimicrobial resistance in enterococci complicates treatment.
  • Vancomycin resistance is a significant clinical challenge.

Purpose of the Study:

  • To review mechanisms of vancomycin resistance in enterococci.
  • To discuss the impact of this resistance on clinical management.
  • To highlight implications for microbiology and infection control.

Main Methods:

  • Literature review of resistance mechanisms.
  • Analysis of clinical management strategies.
  • Examination of infection control practices.

Main Results:

  • Detailed overview of genetic and non-genetic resistance mechanisms.
  • Discussion of therapeutic challenges and alternative treatments.
  • Emphasis on the importance of surveillance and control.

Conclusions:

  • Understanding resistance mechanisms is crucial for effective treatment.
  • Integrated strategies are needed for clinical microbiology and infection control.
  • Continued research is essential to combat emerging resistance.

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