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Automated procedure for determination of free aromatic amine in water-soluble radiopaques
Journal of Pharmaceutical Sciences
|April 1, 1975
Abstract:
The determination of free aromatic amine in water-soluble radiopaques by diazotization in 2-methoxyethanol-water, coupling with naphthylethylenediamine, and colorimetry of the azo dye has been automated. Sensitivity, precision, and accuracy are satisfactory for purity testing and stability studies.