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Updated: Jul 25, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 27, 2013
Community thrombolysis in the Coromandel region. Audit of the "Cardiac Events in the Coromandel-Assessment Strategy
C Nunn1, J Lennane, G Marriott
1Department of Cardiology, Waikato Hospital, Hamilton.
Insights
Community thrombolysis significantly reduced treatment times for acute myocardial infarction (MI) patients in New Zealand. This pilot program proved logistically feasible, improving patient outcomes by enabling faster access to critical care.
Area of Science:
- Cardiology
- Emergency Medicine
- Health Services Research
Background:
- Acute myocardial infarction (MI) requires rapid intervention to minimize cardiac damage.
- Geographic remoteness can delay access to time-sensitive treatments like thrombolysis.
- A pilot program was initiated in the Coromandel region to address treatment delays.
Purpose of the Study:
- To audit the feasibility and impact of a community thrombolysis pilot program.
- To evaluate the time efficiency of pre-hospital thrombolysis compared to in-hospital treatment.
Main Methods:
- Nineteen patients in the Coromandel region received community thrombolysis (Retelapse) between July 1998 and December 1999.
- ECGs were digitally transmitted for remote review by a cardiology registrar.
- Treatment times and patient demographics were prospectively recorded; outcomes were reviewed via chart analysis. A historical cohort receiving in-hospital thrombolysis was used for comparison.
Main Results:
- Community thrombolysis was administered to 19 patients, with no adverse events during transport or hospital stay.
- Median time from pain onset to thrombolysis was 135 minutes, a 135-minute reduction compared to the historical cohort (median 270 minutes).
- This time reduction was statistically significant (p=0.0003).
Conclusions:
- Community thrombolysis is logistically feasible in the New Zealand context.
- This approach significantly reduces treatment delays for acute myocardial infarction (MI) patients.
- The findings support the expansion of community-based thrombolysis programs.
Aim:
To audit the experience of a pilot program for community thrombolysis undertaken within the Coromandel region.
Methods:
Community thrombolysis for patients suffering acute myocardial infarction (MI) was undertaken in areas within the Coromandel peninsula greater than half an hour by road from Thames Hospital. Thrombolytic therapy (Retelapse) was given following a discussion and review of a digitally transmitted ECG with the cardiology registrar. Treatment times and patients demographics were prospectively recorded. Subsequent clinical events were by chart review. Comparison of treatment times were made with an historical cohort for the same population which had received in-hospital thrombolysis between 1993 and 1998.
Results:
Between July 1998 and December 1999, nineteen patients received thrombolysis in the community. There were no arrhythmic events during transportation and no deaths or reinfarctions during hospital stay. Median time from pain onset to thrombolysis was 135 (mean 175.5 +/- 144.9 SD) minutes which equated to a reduction in median time delay of 135 minutes compared to that experienced by the historical cohort (median 270, mean 316.7 +/- 145.8 SD minutes), p=0.0003.
Conclusion:
Community thrombolysis is logistically feasible within the New Zealand setting and results in major time reductions in the treatment of patients with acute MI.
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