Related Experiment Video
Updated: Jul 27, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
Increased serum nitrate levels in infants with atopic dermatitis
S Taniuchi1, T Kojima, K Hara Mt
1Department of Paediatrics, Kansai Medical University, Osaka, Japan.
Serum nitrate levels, indicating nitric oxide (NO) production, are elevated in children with atopic dermatitis (AD) and correlate with disease severity. This suggests NO plays a role in AD skin inflammation.
Area of Science:
- Dermatology
- Immunology
- Biochemistry
Background:
- The exact cause of atopic dermatitis (AD) remains unclear.
- Inducible nitric oxide synthase (iNOS) expression in AD lesions suggests nitric oxide (NO) involvement in skin inflammation.
- Nitrate (NO3) is a stable metabolite of NO, making it a useful marker.
Purpose of the Study:
- To investigate serum nitrate (NO3) levels in children with atopic dermatitis (AD).
- To determine the relationship between serum nitrate levels and AD disease severity.
Main Methods:
- Serum nitrate levels were measured in 88 children with AD and 12 nonatopic controls.
- Measurements were correlated with clinical skin scores and peripheral eosinophil counts.
Main Results:
- Children with AD exhibited significantly higher serum nitrate levels compared to controls.
- Serum nitrate levels positively correlated with AD disease severity.
- Skin scores were also significantly correlated with serum nitrate levels and eosinophil counts.
Conclusions:
- Elevated serum nitrate suggests increased nitric oxide (NO) production in atopic dermatitis (AD).
- Nitric oxide (NO) may contribute to the pathogenesis of vasodilation and erythema in AD skin lesions.
More Related Videos
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
08:23Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Related Concept Videos
2° Amines to N-Nitrosamines: Reaction with NaNO2
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...