Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treating systemic diseases via the lung.

S Sanjar1, J Matthews

  • 1Glaxo Wellcome, Research Triangle Park, North Carolina 27709, USA. ss5480@glaxowellcome.com

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
|June 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The GEMstone Maze: Gamification of Medical Skills and Knowledge.

The clinical teacher·2026
Same author

Energy Spectrum of Ultrahigh-Energy Cosmic Rays across Declinations -90° to +44.8° as Measured at the Pierre Auger Observatory.

Physical review letters·2026
Same author

Search for Light Dark Matter with NEWS-G at the Laboratoire Souterrain de Modane Using a Methane Target.

Physical review letters·2025
Same author

Search for the Anomalous Events Detected by ANITA Using the Pierre Auger Observatory.

Physical review letters·2025
Same author

Inference of the Mass Composition of Cosmic Rays with Energies from 10^{18.5} to 10^{20}  eV Using the Pierre Auger Observatory and Deep Learning.

Physical review letters·2025
Same author

Demonstrating Agreement between Radio and Fluorescence Measurements of the Depth of Maximum of Extensive Air Showers at the Pierre Auger Observatory.

Physical review letters·2024
Same journal

ASTRA Satellite Symposium -"The Importance of Size".

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Aerosols for Medical Applications (GAeF Satellite Meeting).

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Mucus and cilia symposium.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Aerosol delivery systems.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Standardization.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Modeling.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
See all related articles

Pulmonary drug delivery offers rapid action for nonrespiratory diseases, overcoming limitations of current inhalers. Advances in inhalation technology promise new treatments using inhaled peptide hormones and other large molecules.

Area of Science:

  • Pharmacology
  • Pulmonary Medicine
  • Drug Delivery Systems

Background:

  • Inhalation of substances for medicinal purposes has a long history, but its use for treating nonrespiratory diseases is underexplored.
  • Current applications like anesthetics highlight the lung's potential for rapid drug delivery, yet efficiency and patient acceptance remain challenges.
  • Existing inhalation devices struggle with delivering large molecules effectively, and patient compliance with inhalers is often poor.

Purpose of the Study:

  • To explore the potential of pulmonary drug delivery for treating nonrespiratory conditions.
  • To address the limitations of current inhalation devices and improve patient acceptability.
  • To investigate the feasibility of delivering various molecule sizes, including large biologics, via inhalation.

Main Methods:

Related Experiment Videos

  • Review of current pulmonary delivery technologies and their advancements.
  • In vitro studies assessing drug absorption through the alveolar membrane, particularly for lipophilic drugs.
  • Evaluation of animal models to demonstrate improved drug absorption for orally poorly absorbed analgesics and anti-inflammatory drugs.

Main Results:

  • Advances in pulmonary delivery technology are enabling the development of new inhaled drug formulations.
  • In vitro data indicate rapid absorption of lipophilic drugs via the alveolar membrane.
  • Animal studies show enhanced absorption of certain drugs when delivered via inhalation compared to oral administration.

Conclusions:

  • The lung is a viable route for delivering a wide range of molecules, including peptide hormones and biologics, in clinically relevant amounts.
  • Improved inhalation technologies are poised to overcome previous limitations in efficiency and patient acceptance.
  • Inhaled drug delivery presents a promising avenue for developing novel therapeutic formulations for nonrespiratory diseases.