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Biotin labelling of amines by polymer-assisted solution-phase synthesis
A Golisade1, C Herforth, K Wieking
1Universität Hamburg, Institut für Pharmazie, Bundesstrasse 45, D-20146, Hamburg, Germany.
Bioorganic & Medicinal Chemistry Letters
|June 27, 2001
Abstract:
An efficient and simple polymer-assisted approach has been developed to biotinylate multifunctional compounds bearing an amino functionality. Biotin was immobilized on aminomethylated polystyrene via the Kenner safety catch linker, activated and subsequently transferred to the amino function of the target compounds chemoselectively, thus avoiding protecting group operations. This approach holds potential for the introduction of spacer-modified biotin derivatives.