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Urinary PGE(2) concentrations measured by a new EIA method in infants with urinary tract infections or renal

L Cuzzolin1, P Mangiarotti, V Fanos

  • 1Department of Medicine & Public Health--Section of Pharmacology, University of Verona, Policlinico Borgo Roma, 37134 Verona, Italy. lcuzzolin@univr.it

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|June 28, 2001
PubMed

Insights

Urinary prostaglandin E2 (PGE2) levels are higher in infants with recurrent urinary tract infections (UTIs) or kidney malformations. This non-invasive urine test may aid in diagnosing obstructive uropathies and monitoring kidney function.

Area of Science:

  • Pediatric Nephrology
  • Biochemistry

Background:

  • Recurrent urinary tract infections (UTIs) and renal malformations are significant health concerns in infants.
  • Accurate diagnosis and monitoring of renal function are crucial for managing these conditions.

Purpose of the Study:

  • To investigate urinary prostaglandin E2 (PGE2) concentrations in infants with recurrent UTIs or renal malformations.
  • To evaluate the potential of urinary PGE2 as a non-invasive biomarker for differential diagnosis and renal function monitoring.

Main Methods:

  • A novel enzyme immunoassay (EIA) method was used to measure PGE2 concentrations in urine samples.
  • Urine samples were collected from infants with recurrent UTIs, renal malformations, and healthy controls.

Main Results:

  • Urinary PGE2 excretion rates were significantly higher in infants with recurrent UTIs and renal malformations compared to healthy controls.
  • Subjects with obstructive uropathies exhibited particularly elevated PGE2 levels (29.55+/-8.12 pg/ml) compared to non-obstructive cases (18.37+/-4.64 pg/ml).
  • No significant correlations were found between PGE2 excretion and age, urine pH, or other renal function indices.

Conclusions:

  • Urinary PGE2 is a potential non-invasive biomarker for differentiating obstructive from non-obstructive renal dilatation in infants.
  • Measuring urinary PGE2 may assist in monitoring renal function in infants experiencing recurrent UTIs.

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