Substituted amylose as a matrix for sustained-drug release: a biodegradation study

Area of Science:

• Polymer Chemistry
• Materials Science
• Pharmaceutical Sciences

Background:

• Substituted amylose polymers are novel excipients for controlled release applications.
• Amylose-based polymers are susceptible to biodegradation by alpha-amylase in the gastro-intestinal tract.
• Developing robust drug delivery systems requires understanding polymer stability and release kinetics.

Purpose of the Study:

• To synthesize substituted amylose polymers using glycidol.
• To evaluate the controlled release of a model drug (rhenium (VII) oxide) from these polymers.
• To assess the resistance of substituted amylose dosage forms to alpha-amylase enzymatic degradation.

Main Methods:

• Substituted amylose polymers were synthesized by reacting amylose with glycidol.
• Two solid dosage forms were prepared: matrix systems and dry-coated tablets.
• Gamma spectroscopy was employed to monitor drug release and polymer degradation.

Main Results:

• Both matrix systems and dry-coated tablets demonstrated controlled release of the rhenium model drug.
• The substituted amylose dosage forms exhibited significant resistance to alpha-amylase enzymatic degradation.
• The structural integrity of the dosage forms was maintained throughout the study.

Conclusions:

• Substituted amylose polymers are effective excipients for controlled drug delivery.
• These polymers offer a promising biodegradable alternative for pharmaceutical formulations.
• The developed dosage forms show stability in the gastro-intestinal environment, ensuring predictable drug release.