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Characterization of multidrug-resistant Salmonella enterica serovar Typhimurium isolated in Japan

H Izumiya1, J Terajima, S Matsushita

  • 1Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan.

Journal of Clinical Microbiology
|June 28, 2001
PubMed

Insights

Multidrug-resistant Salmonella Typhimurium strains, particularly definitive phage type 104, are prevalent in Japan. These strains share similar drug resistance and genetic profiles with those found in Western countries, indicating potential international spread of resistant bacteria.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Multidrug-resistant Salmonella enterica serovar Typhimurium poses a significant global health threat.
  • Understanding the genetic characteristics and resistance patterns of prevalent strains is crucial for effective control strategies.

Purpose of the Study:

  • To characterize multidrug-resistant Salmonella Typhimurium isolates from Japan.
  • To compare the genetic and drug resistance profiles of Japanese isolates with those from other regions.

Main Methods:

  • Bacterial isolates were collected and characterized.
  • Drug resistance patterns were determined.
  • Integron types and pulsed-field gel electrophoresis (PFGE) patterns were analyzed.

Main Results:

  • A total of 221 multidrug-resistant Salmonella Typhimurium isolates were studied.
  • Clonal definitive phage type 104 strains were predominant.
  • These strains exhibited resistance patterns, integron types, and PFGE patterns similar to prevalent Western isolates.

Conclusions:

  • The findings highlight the prevalence of specific multidrug-resistant Salmonella Typhimurium clones in Japan.
  • The genetic similarity to Western strains suggests potential international dissemination pathways.
  • This underscores the need for global surveillance of antimicrobial resistance in Salmonella.

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