Related Experiment Video

Updated: May 5, 2026

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
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An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

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Salmonella enterica serotype Paratyphi A carrying CTX-M-15 type extended-spectrum beta-lactamase isolated from a

M Mawatari1, Y Kato, K Hayakawa

  • 1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|November 22, 2013
PubMed

Insights

Multidrug-resistant Salmonella Paratyphi A, a growing public health threat, was identified. This marks the first reported case of this specific resistant strain in a Japanese traveler returning from India.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Salmonella Typhi and Salmonella Paratyphi are significant causes of enteric fever globally.
  • Emerging antimicrobial resistance in these pathogens poses a substantial public health challenge.
  • The spread of drug-resistant bacteria is a critical concern for international travelers and public health surveillance.

Observation:

  • A Japanese traveler returning from India was diagnosed with an infection.
  • The causative agent was identified as Salmonella Paratyphi A.
  • This isolate exhibited resistance to multiple antimicrobial drugs.

Findings:

  • The study reports the first isolation of multidrug-resistant Salmonella Paratyphi A carrying the CTX-M-15 extended-spectrum beta-lactamase (ESBL) enzyme.
  • The CTX-M-15 ESBL confers resistance to key antibiotics, including third-generation cephalosporins.
  • This finding highlights the emergence of specific resistance mechanisms in Salmonella Paratyphi A.

Implications:

  • This case underscores the importance of robust travel health screening and antimicrobial stewardship.
  • The presence of CTX-M-15 in Salmonella Paratyphi A necessitates enhanced monitoring and diagnostic strategies.
  • This highlights the potential for international spread of multidrug-resistant enteric fever pathogens.

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