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[Synthesis and pharmacological study of 7-phenyl-1,4-diazepin-5-one and its derivatives]
M Chammache1, A Zellou, E M Essassi
1Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, Avenue Ibn Battouta, BP 1014 Rabat (Maroc).
Annales Pharmaceutiques Francaises
|June 28, 2001
Abstract:
We studied the synthesis and psychotropic activity of the 7-phenyl-1,4-diazepin-5-one and derivatives. It can be conclude that these products have sedative, myorelaxant and anxiolytic actions. The toxicity study demonstrated that two diazepines are non-toxic at therapeutic dosages but that a third compound is very toxic.