Maintenance of homeostasis of endogenous ethanol as a method for the therapy of alcoholism
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Updated: Oct 5, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
1Department for the Therapy of Alcohol Dependence, V. M. Bekhterev Psychoneurological Institute, St. Petersburg.
Abstract:
We propose a new method for the therapy of alcoholism based on maintenance of homeostasis of endogenous ethanol and inhibition of alcohol dehydrogenase with emetine. After the standard antialcohol therapy, activity of this enzyme remained high or even increased, and pathological alcohol addiction also increased. Emetine normalized activity of alcohol dehydrogenase and suppressed pathological alcohol addiction. After this therapy more than 50% patients achieved stable remissions from alcoholism over 1 year, which indicated high efficiency of the proposed method.
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