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Effect of ionic carbohydrate-containing biopolymers on complement activation
I V Nazarova1, Y S Khotimchenko, N M Shevchenko
1Institute of Sea Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok.
Bulletin of Experimental Biology and Medicine
|June 28, 2001
Abstract:
We studied in vitro effects of charged polysaccharides on the classic and alternative pathways of complement activation. The complement system was affected by substances having different charges. Our findings suggest that the conformation of polysaccharide molecules, but not their charge, plays a primary role in the interaction with C1 and C3 complement components followed by initiation of cascade enzymatic reactions.