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Updated: Oct 5, 2026
A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
Published on: November 15, 2024
Analgesic effect of olipiphate on mouse model of chemical stimulation of peritoneum
E E Zvartau1, N A Patkina, V A Kashkin
1I. P. Pavlov Medical University, St. Petersburg. zvartau@spmu.rssi.ru
Abstract:
We studied the analgesic effect of olipiphate, a product of lignin, against writhing provoked by intraperitoneal injection of acetic acid. Paracetamol was used as the reference drug. Both agents dose-dependently decreased the number of motor reactions caused by the irritant. Olipiphate possessed analgesic activity and efficiency comparable with those of paracetamol, but produced a more long-lasting effect.
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