Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracellular matrix remodeling in the vascular wall.

M P Jacob1, C Badier-Commander, V Fontaine

  • 1INSERM U 460, UFR de médecine Xavier Bichat, 16, rue Henri Huchard 75870 Paris, France. jacob@bichat.inserm.fr

Pathologie-Biologie
|June 29, 2001
PubMed
Summary

Vascular extracellular matrix (ECM) integrity is crucial for vessel health. Injury disrupts the protease/inhibitor balance, leading to suboptimal ECM repair and potential adverse effects, necessitating careful management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a virtual interprofessional oral-systemic health simulation experience in nursing, dentistry, medicine, and pharmacy education.

Journal of dental education·2024
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Periodontitis and Cardiovascular Diseases. Consensus Report.

Global heart·2020

Area of Science:

  • Vascular Biology
  • Biochemistry
  • Pathology

Background:

  • The extracellular matrix (ECM) provides structural integrity to vessel walls.
  • Optimal ECM organization, established during fetal development, is vital for vascular function.
  • Vascular injury initiates processes that degrade ECM components.

Purpose of the Study:

  • To examine the role of extracellular matrix and protease activity in vascular health and disease.
  • To understand the impact of injury and inflammation on vascular ECM.
  • To evaluate the regenerative capacity of smooth muscle cells in response to vascular injury.

Main Methods:

  • Analysis of extracellular matrix composition and organization in healthy and diseased vessels.
  • Investigation of protease and protease inhibitor expression and activity.

Related Experiment Videos

  • Assessment of smooth muscle cell response to injury and their role in ECM remodeling.

    • Main Results:

    • Vascular injury, including inflammation, leads to protease-mediated ECM hydrolysis.
    • Pathological conditions disrupt the balance between proteases and inhibitors, impairing ECM repair.
    • Smooth muscle cells attempt to repair ECM but produce functionally suboptimal matrix.

    Conclusions:

    • Maintaining vascular ECM reserve is critical for preventing adverse outcomes.
    • Therapeutic interventions targeting the protease/inhibitor balance require precise control to avoid detrimental ECM accumulation.
    • Vascular pathologies highlight the complex interplay between ECM, proteases, and cellular responses.