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Antifungal constituent from Gordonia dassanayakei
P S Athukoralage1, H M Herath, S A Deraniyagala
1Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka.
Fitoterapia
|June 29, 2001
Summary
The hexane extract of Gordonia dassanayakei stem bark exhibits potent antifungal activity against key plant pathogens. A specific compound, 3-formyl-2,4-dihydroxy-6-methylbenzoic acid 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl ester, was identified as the active agent.
Area of Science:
- Phytochemistry
- Plant Pathology
- Organic Chemistry
Background:
- Plant pathogenic fungi cause significant agricultural losses worldwide.
- Natural products are a valuable source for novel antifungal agents.
- Gordonia dassanayakei is a plant species with potential medicinal properties.
Purpose of the Study:
- To investigate the antifungal activity of Gordonia dassanayakei stem bark extract.
- To isolate and identify the compound responsible for the observed antifungal effects.
Main Methods:
- Hexane extraction of Gordonia dassanayakei stem bark.
- Bioassay-guided fractionation to isolate active compounds.
- Spectroscopic methods (e.g., NMR, MS) for compound identification.
Main Results:
- The hexane extract demonstrated high antifungal activity against Curvularia sp., Colletotrichum gloeosporioides, Rhizoctonia solani, Corynespora cassiicola, and Fusarium sp.
- A pure compound was isolated and identified as 3-formyl-2,4-dihydroxy-6-methylbenzoic acid 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl ester (1).
Conclusions:
- Gordonia dassanayakei stem bark is a promising source of natural antifungal compounds.
- The identified ester possesses significant potential for controlling plant pathogenic fungi.
- Further research into the mechanism of action and application of this compound is warranted.