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Intramolecular 1,3-dipolar cycloadditions of norbornadiene-tethered nitrile oxides
C Yip1, S Handerson, G K Tranmer
1Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
The Journal of Organic Chemistry
|June 30, 2001
Abstract:
Efficient routes to the synthesis of norbornadiene-tethered nitrile oxides have been developed, and their intramolecular 1,3-dipolar cycloadditions were studied. The cycloadditions occurred in good yields for a variety of substrates and were found to be highly regio- and stereoselective, giving single regio- and stereoisomers in most cases.