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Updated: Sep 6, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium(II)-Catalyzed Regioselective C(sp3)-H Selenylation of 8-Methylquinoline Derivatives
Xiaochun Cao1, Ran He1, Chengcui Xiong1
1Antibiotics Innovation and Resistance Control Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu610106, People's Republic of China.
Abstract:
We report the first ligand-free palladium(II)-catalyzed regioselective C(sp3)-H selenylation of 8-methylquinoline derivatives using aryl selenenyl chlorides as the selenating reagents. The reaction proceeds smoothly over a broad range of substrates with excellent regioselectivity, affording the corresponding selenium-containing quinoline derivatives in good to high yields. The protocol does not require external ligands, is amenable to scale-up, and tolerates a wide variety of functional groups. Preliminary synthetic applications demonstrate the potential utility of this method in medicinal chemistry.
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