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Related Experiment Videos

Dwarf8 polymorphisms associate with variation in flowering time.

J M Thornsberry1, M M Goodman, J Doebley

  • 1Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA.

Nature Genetics
|June 30, 2001
PubMed
Summary
This summary is machine-generated.

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This study adapted statistical methods for plant genetics, revealing that maize gene Dwarf8 polymorphisms are linked to flowering time variations. These findings suggest Dwarf8 has been influenced by natural selection in maize.

Area of Science:

  • Plant Genetics
  • Quantitative Genetics
  • Maize Breeding

Background:

  • Association tests are common in human genetics but underutilized in plant genetics due to population structure.
  • Maize gene Dwarf8 is a candidate for influencing flowering time and plant height, with wheat orthologs linked to 'Green Revolution' yields.

Purpose of the Study:

  • To extend statistical methods for accounting for population structure in quantitative variation analysis.
  • To evaluate Dwarf8 sequence polymorphisms in maize using association approaches.

Main Methods:

  • Bayesian analysis of 141 simple sequence repeat (SSR) loci to estimate population structure.
  • Association analysis of Dwarf8 sequence polymorphisms in 92 maize inbred lines.

Main Results:

Related Experiment Videos

  • A set of polymorphisms in Dwarf8 were found to associate with differences in maize flowering time.
  • A deletion polymorphism potentially affecting a key coding domain was identified.
  • The distribution of nonsynonymous polymorphisms indicates Dwarf8 has been under selection.

Conclusions:

  • Statistical methods accounting for population structure can be effectively applied to maize genetics.
  • Dwarf8 is a significant gene influencing flowering time in maize and has undergone selection.
  • Findings contribute to understanding genetic variation for crop improvement.