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Borna disease virus and human disease.

K M Carbone1

  • 1FDA/CBER, HFM 460, 8800 Rockville Pike, Bethesda, MD 20892, USA. Carbonek@cber.fda.gov

Clinical Microbiology Reviews
|July 4, 2001
PubMed
Summary

Human Borna disease virus (BDV) infection is plausible, but definitive proof and disease links require validated diagnostic assays. Further research is crucial to confirm human BDV infection and its associated diseases.

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Area of Science:

  • Virology
  • Infectious Diseases
  • Neuroscience

Background:

  • Borna disease virus (BDV) biology suggests potential for human infection.
  • Current evidence for human BDV infection is controversial and lacks definitive validation.
  • No human diseases have been causally linked to BDV infection to date.

Purpose of the Study:

  • To address the controversy surrounding human Borna disease virus (BDV) infection.
  • To highlight the need for validated diagnostic assays to confirm human BDV infection.
  • To emphasize the importance of rigorous methodology in clinical studies investigating BDV and disease associations.

Main Methods:

  • Review of existing evidence on BDV biology and potential human transmission.
  • Discussion of the requirements for developing and validating diagnostic assays for human BDV infection.
  • Emphasis on the necessity of sensitive and specific assays for clinical research.

Main Results:

  • The biological basis for potential human BDV infection is strong.
  • A significant gap exists in validated diagnostic tools for human BDV detection.
  • Current clinical studies lack the necessary assays to reliably confirm BDV infection status.

Conclusions:

  • Validated diagnostic assays are essential to confirm or refute human BDV infection.
  • Rigorous, validated testing is required before associating BDV with specific human diseases.
  • Ongoing research is critical to resolve the questions surrounding human BDV infection and its clinical implications.

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