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Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
15:43

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes

Published on: January 7, 2013

The role of protein kinase C isoforms in insulin action

P Formisano1, F Beguinot

  • 1Department of Biology and Cellular and Molecular Pathology L. Califano, Federico II University of Naples, Italy. fpietro@unina.it

Journal of Endocrinological Investigation
|July 4, 2001
PubMed

Insights

Insulin signaling involves tyrosine kinase receptors and protein kinase C (PKC) activation. This review explores how insulin activates PKC isoforms and their dual roles in both insulin action and resistance.

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Endocrinology

Background:

  • Insulin action is initiated by insulin receptors, which are tyrosine kinases.
  • Insulin receptor activation leads to substrate phosphorylation and subsequent enzyme activation, including protein kinase C (PKC).
  • Multiple PKC isoforms exist, suggesting complex roles in cellular signaling.

Purpose of the Study:

  • To analyze the mechanisms by which insulin activates individual PKC isoforms.
  • To elucidate the specific roles of different PKC isoforms in insulin-induced biological effects.
  • To understand the contribution of PKC isoforms to insulin resistance.

Main Methods:

  • Review of experimental evidence on insulin signaling pathways.
  • Analysis of studies investigating PKC isoform activation by insulin.
  • Examination of research linking PKC activity to insulin sensitivity and resistance.

Main Results:

  • Insulin activates specific PKC isoforms through its receptor tyrosine kinase activity.
  • PKC isoforms play a dual role, mediating insulin signal transduction and contributing to insulin resistance.
  • The specific PKC isoform activated influences the downstream cellular response.

Conclusions:

  • Understanding PKC isoform activation by insulin is crucial for deciphering insulin signaling.
  • Targeting specific PKC isoforms may offer therapeutic strategies for metabolic disorders.
  • PKC's complex role highlights the intricate nature of insulin resistance development.

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