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Related Concept Videos

Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
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Ischemic Stroke l: Introduction01:15

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Related Experiment Video

Updated: May 7, 2026

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

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Published on: January 13, 2012

Ultrasonic echolucent carotid plaques predict future strokes.

M L Grønholdt1, B G Nordestgaard, T V Schroeder

  • 1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan. mlg@dadlnet.dk

Circulation
|July 4, 2001
PubMed
Summary

Echolucent carotid plaques predict stroke risk in symptomatic patients, but not asymptomatic ones. Plaque echolucency and stenosis degree may improve stroke risk assessment and patient selection for carotid endarterectomy.

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Last Updated: May 7, 2026

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

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Published on: January 13, 2012

Ultrasonic Assessment of Myocardial Microstructure
10:53

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Published on: January 14, 2014

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Area of Science:

  • Neurology
  • Vascular Medicine
  • Medical Imaging

Background:

  • Carotid artery stenosis is a significant risk factor for ischemic stroke.
  • Predicting stroke risk in patients with carotid atherosclerosis remains a clinical challenge.
  • Plaque characteristics, such as echolucency, may offer prognostic value.

Purpose of the Study:

  • To prospectively evaluate if carotid plaque echolucency predicts stroke development.
  • To assess this prediction in both previously symptomatic and asymptomatic patients.
  • To determine if echolucency improves stroke risk stratification beyond stenosis degree.

Main Methods:

  • Prospective study of 246 patients (111 asymptomatic, 135 symptomatic) with >=50% carotid artery stenosis.
  • High-resolution B-mode ultrasound with computer-assisted image processing assessed plaque echogenicity.
  • Doppler ultrasound evaluated the degree of carotid artery stenosis.
  • Follow-up for ipsilateral ischemic strokes over 4.4 years.

Main Results:

  • 44 ipsilateral ischemic strokes were observed during follow-up.
  • In symptomatic patients, echolucent plaques significantly increased stroke risk (Relative Risk = 3.1).
  • Higher stenosis (80-99%) showed a trend towards increased risk (RR=1.4) in symptomatic patients, but echolucency was a stronger predictor.
  • No significant association between plaque echolucency and stroke risk was found in asymptomatic patients.

Conclusions:

  • Echolucent carotid plaques are associated with future stroke risk in symptomatic individuals with significant stenosis.
  • Plaque echolucency, in addition to stenosis severity, may enhance patient selection for carotid endarterectomy.
  • This imaging marker does not appear to predict stroke risk in asymptomatic patients with carotid stenosis.