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Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos
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Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants

S A Krause1, M L Loupart, S Vass

  • 1Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

Molecular and Cellular Biology
|July 5, 2001
PubMed
Summary

Mutations in the Drosophila Rfc4 gene disrupt DNA replication and cause mitotic chromosome defects by impairing checkpoint control, not direct chromosome structure. This highlights RFC4

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