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Compaction properties of L-lysine salts.
1Department of Pharmaceutics, University of Minnesota, Minneapolis 55455-0343, USA.
Pharmaceutical Research
|July 10, 2001
Summary
The salt form significantly impacts L-lysine salt tablet properties. Tensile strength depends on yield strength at low pressures and interparticulate bonding at high pressures.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Tabletability is crucial for drug formulation.
- Understanding salt form effects on compaction is vital for pharmaceutical development.
Purpose of the Study:
- To investigate how different anions affect L-lysine salt compaction.
- To determine factors influencing tablet tensile strength.
Main Methods:
- Compressed L-lysine salts with various anions (acetate, chloride, aspartate, glutamate) at different pressures.
- Evaluated salt yield strength using Heckel plots.
Main Results:
- Tablet tensile strength increased with compaction pressure at low pressures.
- Tensile strength decreased with increasing salt yield strength at low pressures.
- At high pressures, interparticulate bonding strength determined tensile strength.
Conclusions:
- Counterions influence L-lysine salt tableting properties.
- Tensile strength is governed by yield strength and interparticulate interactions.
- Melting temperature predicts zero-porosity tensile strength.