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Updated: Jul 17, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
A multivariate ANN-CCD integrative model using cellulose based polymers for the development of osmotically controlled
Nazish Mumtaz1, Rabia Ismail Yousuf1, Muhammad Harris Shoaib1
1Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, 75270, Pakistan.
Summary
Biocompatible macromolecules enhance dexibuprofen (a poorly compressible drug) delivery using bilayer push-pull osmotic tablets. This approach optimizes drug release and improves in vivo pharmacokinetic performance over 12 hours.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biotechnology
Background:
- Biocompatible macromolecules are crucial for advanced drug delivery systems.
- Developing effective drug delivery for poorly compressible drugs like dexibuprofen presents significant challenges.
- Osmotic drug delivery systems offer controlled release but require careful formulation.
Purpose of the Study:
- To develop and optimize a bilayer push-pull osmotic tablet for dexibuprofen using biocompatible macromolecules.
- To investigate the role of polyethylene oxide and microcrystalline cellulose in tablet formulation.
- To achieve a targeted 12-hour drug release profile for dexibuprofen.
Main Methods:
- Formulation of bilayer tablets using cellulose acetate, polyethylene oxide (Polyox WSR N 80, Polyox WSR 303), and microcrystalline cellulose.
- Optimization of formulation variables (osmogen, orifice size, coating) using Artificial Neural Network (ANN) and Central Composite Design (CCD).
- Evaluation of physicochemical properties, stability, and in vivo pharmacokinetic performance using Physiologically Based Pharmacokinetic (PBPK) modeling.
Main Results:
- Successful development of a bilayer push-pull osmotic tablet system for dexibuprofen.
- ANN and CCD models effectively optimized formulation parameters for targeted drug release.
- Improved tabletability of dexibuprofen by incorporating microcrystalline cellulose.
- Optimized formulations demonstrated favorable stability, physicochemical characteristics, and simulated in vivo performance.
Conclusions:
- Biocompatible macromolecules, specifically polyethylene oxide and microcrystalline cellulose, are effective in formulating poorly compressible drugs like dexibuprofen into osmotic systems.
- The developed push-pull osmotic system successfully modulates dexibuprofen release and enhances its in vivo pharmacokinetic profile over 12 hours.
- The combination of ANN, CCD, and PBPK modeling provides a robust framework for optimizing complex drug delivery systems.
Keywords:
Artificial neural networkCentral composite design: PBPKControlled releaseDexibupurofenOsmotic push pull systemQbDMore Related Videos
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