Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate.

J Dopazo1, A Mendoza, J Herrero

  • 1Research Department, GlaxoSmithKline S.A., Tres Cantos, Spain.

Microbial Drug Resistance (Larchmont, N.Y.)
|July 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of extended and seasonal calving systems on milk composition and heat coagulation time in a pasture-based dairy herd.

JDS communications·2026
Same author

Age-related and disease-specific changes in B-cell profiles in older adults with immune thrombocytopenia.

Frontiers in immunology·2026
Same author

Enhancing Emergency Medicine Services at Rural Outreach Centers: A Comprehensive Needs Assessment for Project ECHO Education Program.

Kathmandu University medical journal (KUMJ)·2026
Same author

XNet: Enhancing Physical Activity Intensity Assessment With Attentional Multidomain Fusion and Visual Analytics.

IEEE transactions on cybernetics·2026
Same author

Prepartum management factors associated with the development of calcium imbalance during the first days postpartum in grazing dairy cows in Uruguay.

Preventive veterinary medicine·2025
Same author

Drug management of TB in the intensive care setting: an international multicentre study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same journal

Trends, Patterns, and Demographic Dynamics of Drug Resistance in <i>Mycobacterium tuberculosis</i> and Nontuberculous: A Multi-Year Analysis at the National Tuberculosis Reference Laboratory.

Microbial drug resistance (Larchmont, N.Y.)·2026
Same journal

Ceftazidime-Avibactam/Colistin Combination Against Carbapenem-Resistant <i>Pseudomonas aeruginosa: In Vitro</i> Synergy Indicating a Possible Therapeutic Approach.

Microbial drug resistance (Larchmont, N.Y.)·2026
Same journal

Rapid Screening of <i>Klebsiella pneumoniae</i> Isolates Reveals Multidrug-Resistant and Virulence Traits in a Tertiary Level Hospital in Panama.

Microbial drug resistance (Larchmont, N.Y.)·2026
Same journal

Clinical Characteristics and Genomic Analysis of Vancomycin-Resistant <i>Enterococcus faecium</i> in a Tertiary Hospital in Huizhou.

Microbial drug resistance (Larchmont, N.Y.)·2026
Same journal

Burden of Carbapenemase-Producing Enterobacterales in Critical Care Settings: Insights from a Tunisian Intensive Care Unit.

Microbial drug resistance (Larchmont, N.Y.)·2026
Same journal

Distribution of Tetracycline and β-Lactam Resistance Genes in the Oropharyngeal and Anorectal Mucosa of Men Who Have Sex with Men: An Exploratory Study.

Microbial drug resistance (Larchmont, N.Y.)·2026
See all related articles

This study presents the genome sequence and functional annotations for Streptococcus pneumoniae, a major global pathogen. The findings offer detailed insights into pneumococcal biology and antibiotic resistance mechanisms.

Area of Science:

  • Microbiology
  • Genomics
  • Bacterial Pathogenesis

Background:

  • Streptococcus pneumoniae is a significant global bacterial pathogen.
  • Advances in microbial genomics enable detailed, organism-wide analyses.
  • Understanding pneumococcal genomics is crucial for public health.

Purpose of the Study:

  • To present the genome sequence and functional annotations of a clinical isolate of Streptococcus pneumoniae.
  • To provide a comprehensive analysis of pneumococcal DNA, covering over 90% of the genome.
  • To facilitate comparative genomics studies of bacterial pathogens.

Main Methods:

  • Whole-genome sequencing of a clinical isolate of Streptococcus pneumoniae.
  • Functional annotation of identified open reading frames (ORFs).

Related Experiment Videos

  • Multilocus sequence typing (MLST) for genetic lineage determination.
  • Comparative genomic analysis against other bacterial genomes.

    • Main Results:

    • Sequencing of 2.1-Mbp of pneumococcal DNA, representing over 90% of the genome.
    • Identification of 2,046 putative open reading frames (ORFs) longer than 100 amino acids.
    • Characterization of a clinical isolate resistant to macrolides and tetracycline.
    • Determination of a type 19F capsular locus, with MLST suggesting a lineage typically expressing serotype 15.

    Conclusions:

    • The genome sequence provides a valuable resource for studying Streptococcus pneumoniae.
    • The findings highlight genetic diversity within pneumococcal lineages.
    • The characterized isolate offers insights into antibiotic resistance in this important pathogen.