[Changes in the sensitivity of lipoatrophic tissues to insulin under the effects of novocaine]

A study was made of the isolated adipose tissue of 9 healthy women and the adipose tissue from the zone of lipoatrophy obtained from 7 women suffering from diabetes mellitus treated with insulin. In difference to the adipose tissue of healthy persons, in the lipoatrophic adipose tissue there occurred under the effect of insulin-novocain mixture a marked increase in the incorporation of C-14-labeled glucose into the total lipids of the adipose tissue. The data obtained served as an argument in favour of the neurotrophic genesis of the postinjection insulin lipoatrophies and proved the neuro-trophic mechanism of the therapeutic effect of the insulin-novocain mixture.