Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metrazol impairs conditioned aversion produced by LiCl: a time dependent effect.

J R Millner, T Palfai

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Positive alcohol expectancies and drinking behavior: the influence of expectancy strength and memory accessibility.

    Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors·2001
    Same author

    Influence of naltrexone on cue-elicited craving among hazardous drinkers: the moderational role of positive outcome expectancies.

    Experimental and clinical psychopharmacology·1999
    Same author

    Effects of naltrexone on alcohol self-administration in heavy drinkers.

    Alcoholism, clinical and experimental research·1999
    Same author

    Prepulse inhibition of the startle reflex: preliminary study of the effects of a low dose of alcohol in humans.

    Alcoholism, clinical and experimental research·1997
    Same author

    Housing influences exploration and social interaction of control and DSP-4-treated rats.

    Physiology & behavior·1992
    Same author

    Impaired hoarding and olfactory learning in DSP-4-treated rats and control cagemates.

    Pharmacology, biochemistry, and behavior·1990
    Same journal

    Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

    Pharmacology, biochemistry, and behavior·2026
    See all related articles

    Metrazol did not affect conditioned taste aversion when given shortly before or after LiCl. However, it impaired aversion when administered with specific timing relative to LiCl, suggesting a time-dependent effect.

    Area of Science:

    • Neuroscience
    • Behavioral Psychology
    • Pharmacology

    Background:

    • Conditioned taste aversion is a learned response to avoid substances that cause illness.
    • Metrazol (pentylenetetrazol) is a drug known to induce seizures and affect central nervous system function.
    • Understanding how drugs interact with learning and memory processes is crucial for neuroscience and psychology.

    Purpose of the Study:

    • To investigate the effects of Metrazol on the acquisition of a conditioned saccharin aversion.
    • To determine if the timing of Metrazol administration influences its effect on conditioned taste aversion.
    • To explore the relationship between Metrazol, electroconvulsive shock (ECS), and memory processes.

    Main Methods:

    • Two experiments were conducted using rats to assess conditioned taste aversion.

    Related Experiment Videos

  • Saccharin was used as the conditioned stimulus (CS) and lithium chloride (LiCl) as the unconditioned stimulus (UCS).
  • Metrazol was administered at various time points before and after LiCl to evaluate its impact on aversion learning.

    • Main Results:

    • Metrazol administered 10 minutes before or after LiCl did not impair the conditioned saccharin aversion.
    • When Metrazol was administered 2 minutes before, or 3 or 9 minutes after LiCl, a significant impairment of conditioned taste aversion was observed.
    • These findings indicate a time-dependent effect of Metrazol on conditioned taste aversion.

    Conclusions:

    • Metrazol's ability to impair conditioned taste aversion is dependent on the temporal relationship between its administration and the conditioning event (LiCl).
    • The results suggest Metrazol may interfere with memory consolidation or retrieval processes in a time-sensitive manner.
    • Further research is needed to elucidate the precise mechanisms underlying Metrazol's time-dependent effects on learning and memory, potentially involving retroactive and proactive interference.