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[Isochromanes related to fluoxetine]
1Institut für Pharmazeutische Chemie, Westfälischen Wilhelms-Universität Münster, Germany.
Die Pharmazie
|July 12, 2001
Abstract:
The structure of fluoxetin (1) led to the substituted 3'-phenyl-1'-isochromanyl-2-ethylamines 4-9. These are synthesized by ring closure of the 1,2-diphenylethanols 2a-c with 3-chloropropanal-diethylacetal/BF3-etherate and reaction of the chlorides 3a-c with amines. The affinities to the 5-HT2A-receptor and the serotonin transporter are tested.