Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microscopic polyangiitis associated with sinobronchial syndrome.

T Nagata1, K Hara, T Oka

  • 1Second Department of Medicine, University of Tokyo.

Internal Medicine (Tokyo, Japan)
|July 12, 2001
PubMed
Summary

A patient with chronic sinobronchial syndrome developed systemic necrotizing vasculitis, leading to organ damage and pneumonia. This case suggests chronic lung inflammation may trigger autoimmune responses like microscopic polyangiitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Picosecond Laser-Induced Photothermal Skin Damage Evaluation by Computational Clinical Trial.

Laser therapy·2020
Same author

Clinical features and treatment of hepatocellular carcinoma in eight patients older than eighty years of age.

Hepato-gastroenterology·2002
Same author

Primary biliary cirrhosis among atomic bomb survivors in Nagasaki, Japan.

Journal of clinical epidemiology·2001
Same author

Synchronized disappearance of serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 in a patient with chronic hepatitis.

Hepatology research : the official journal of the Japan Society of Hepatology·2001
Same author

Changes in titers of antimitochondrial and antinuclear antibodies during the course of primary biliary cirrhosis.

Journal of gastroenterology and hepatology·2001
Same author

Serial changes in enzyme inhibitory antibody to pyruvate dehydrogenase complex during the course of primary biliary cirrhosis.

Journal of clinical laboratory analysis·2000

Area of Science:

  • Pulmonology
  • Rheumatology
  • Pathology

Background:

  • Chronic sinobronchial syndrome, encompassing chronic bronchitis and sinusitis, presents complex clinical challenges.
  • Autoimmune conditions can arise secondary to chronic inflammatory processes.

Observation:

  • A patient with sinobronchial syndrome presented with fever and active lung inflammation on gallium-67 scintigraphy.
  • The patient developed pulmonary hemorrhage and hematuria, responding to steroids, but ultimately succumbed to pneumonia.

Findings:

  • Autopsy confirmed systemic necrotizing vasculitis, consistent with microscopic polyangiitis (MPA).
  • High levels of antineutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO) were detected.
  • Chronic inflammation from sinobronchial syndrome was implicated as a potential trigger for MPA.

Related Experiment Videos

Implications:

  • This case highlights a potential link between chronic sinobronchial inflammation and the development of ANCA-associated vasculitis.
  • Understanding this association may inform diagnostic and therapeutic strategies for patients with sinobronchial syndrome and unexplained systemic inflammation.
  • Further research is warranted to elucidate the mechanisms connecting chronic respiratory inflammation and autoimmune vasculitis.