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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

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Dipyridamole stress ultrasonic myocardial tissue characterization in patients with Kawasaki disease

X Yu1, I Hashimoto, F Ichida

  • 1Department of Pediatrics, Toyama Medical & Pharmaceutical University, Toyama, Japan.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|July 12, 2001
PubMed

Insights

Dipyridamole stress integrated backscatter (IBS) effectively detects myocardial ischemia in children with Kawasaki disease. This non-invasive imaging method shows significant changes in cyclic variation, aiding in diagnosis.

Area of Science:

  • Cardiology
  • Pediatric Imaging
  • Diagnostic Techniques

Background:

  • Kawasaki disease can lead to coronary artery lesions and myocardial damage in children.
  • Assessing myocardial ischemia in pediatric patients requires accurate and sensitive diagnostic tools.

Purpose of the Study:

  • To evaluate the efficacy of dipyridamole stress integrated backscatter (IBS) for detecting myocardial ischemia or damage in children with Kawasaki disease.
  • To compare the diagnostic performance of dipyridamole stress IBS with thallium-201 myocardial imaging.

Main Methods:

  • 31 children with Kawasaki disease underwent echocardiography with dipyridamole stress.
  • Integrated backscatter (IBS) cyclic variation (CV) was assessed at rest and after stress in specific myocardial regions.
  • Results were compared with thallium-201 (Tl-201) myocardial imaging findings.

Main Results:

  • A significant decrease in CV was observed in regions with abnormal Tl-201 distribution after dipyridamole stress.
  • Delayed imaging showed recovery of CV to baseline levels in all patients.
  • Dipyridamole stress IBS demonstrated high sensitivity (75-91%) and specificity (90-91%) compared to Tl-201 imaging.

Conclusions:

  • Dipyridamole stress IBS is a sensitive method for detecting myocardial ischemia or damage in pediatric patients with Kawasaki disease.
  • This technique offers a valuable non-invasive approach for evaluating coronary artery complications in Kawasaki disease.

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