[Systemic complications of extended burns]

Burns covering more than 10% of the total body surface area (TBSA) are responsible for systemic perturbations which, in very severe cases, can represent a vital risk and, in all cases, affect the wound evolution. Among these general perturbations, fluid volume and electrolyte changes, leading eventually to burn shock, have the most dramatic consequences. Burn shock is, still to day, a vital risk and can also, in case of inadequate early fluid resuscitation, results in secondary morbidity and mortality. Fluid replacement during the very first hours after injury represents certainly a key point of the management of severe burn cases. Estimation of resuscitation fluid needs during this period is frequently underestimated. For adult, we recommend, during the first hour, a minimum of one liter for all severe injuries and two liters if the injury exceeds 50% of TBSA. Pulmonary injuries due to smoke inhalation are frequent, about 25% of patients hospitalized in burn units, and responsible for numerous death at site of house fires. In burn units, about 25% of hospitalized patients have pulmonary injuries in relation with smoke inhalation. This population has a high mortality rate increasing with the area of the skin injury and with age. Patients with inhalation injury need more resuscitation fluids, are subject to pneumonia and necessitate frequently mechanical ventilation. Parameters of the mechanical ventilation have to be choice to avoid barotrauma. Severe burn patients are submitted to a very high metabolic level. This can leads to a deep nutritional deficit responsible for an immunological suppression. It is then of major importance to provide an adequate nutritional support. It is also necessary to fight against the stress and to put the patient in a warm environment. Finally, infection is the most frequent and the most severe complication of burn injuries. Everything have to be done to avoid bacteriological contamination including architecture, equipment's, care procedure, nutritional support, types of wound dressing and most importantly surgery. Surgical procedures have to be done as earliest as possible to excise necrosis and cover the wound.