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Development of the 25-item National Eye Institute Visual Function Questionnaire
C M Mangione1, P P Lee, P R Gutierrez
1Division of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, 911 Broxton Plaza, Box 951736, Los Angeles, CA 90095-1736, USA.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 27, 2001
Summary
The National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) is a reliable and valid measure for assessing visual function in patients with chronic eye diseases. This shorter questionnaire is practical for clinical trials and diverse patient populations.
Area of Science:
- Ophthalmology
- Psychometrics
- Health Outcomes Research
Background:
- Assessing visual function is crucial for managing chronic eye diseases.
- Existing questionnaires, like the 51-item NEI VFQ, can be lengthy for clinical settings.
- A shorter, validated instrument is needed to efficiently capture visual functioning data.
Purpose of the Study:
- To develop and validate a 25-item version of the National Eye Institute Visual Function Questionnaire (NEI VFQ-25).
- To evaluate the psychometric properties of the NEI VFQ-25 in individuals with various chronic eye conditions.
Main Methods:
- A prospective observational cohort study was conducted.
- Participants included individuals with age-related cataracts, AMD, diabetic retinopathy, glaucoma, CMV retinitis, or low vision.
- A reference sample without eye disease was also included.
Main Results:
- The NEI VFQ-25 demonstrated strong internal consistency and reliability.
- Validity was supported by high correlations with the full NEI VFQ, significant between-group differences, and correlations with visual acuity.
- Psychometric properties were robust across different eye conditions and severities.
Conclusions:
- The NEI VFQ-25 is a reliable and valid measure comparable to the longer NEI VFQ.
- Its brevity enhances feasibility in clinical trials and other settings with time constraints.
- The NEI VFQ-25 is suitable for reproducible data collection across diverse eye conditions.

