Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axis formation and patterning in zebrafish.

A F Schier1

  • 1Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, New York, USA. schier@saturn.med.nyu.edu

Current Opinion in Genetics & Development
|July 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans.

American journal of human genetics·2007
Same author

MicroRNA function and mechanism: insights from zebra fish.

Cold Spring Harbor symposia on quantitative biology·2007
Same author

Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo.

Developmental biology·2004
Same author

Single-cell internalization during zebrafish gastrulation.

Current biology : CB·2001
Same author

The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish.

Development (Cambridge, England)·2001
Same author

The zebrafish Nodal signal Squint functions as a morphogen.

Nature·2001
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Zebrafish mutations reveal a complex genetic network controlling early embryonic development. Gene cloning identified key signaling pathways like BMP, Wnt, and FGF, offering new insights into developmental regulation.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular signaling

Background:

  • A 1996 collection of zebrafish mutations impacting embryogenesis is a foundational resource.
  • Understanding the genetic basis of early development is crucial for developmental biology.

Purpose of the Study:

  • To elucidate the roles of specific genes in zebrafish embryogenesis.
  • To reveal the regulatory mechanisms of key signaling pathways in early embryonic patterning.
  • To describe the complex genetic network governing early embryonic development.

Main Methods:

  • Gene cloning and characterization of previously identified mutations.
  • Analysis of signaling pathways including BMP, Nodal, Wnt, FGF, Hedgehog, Delta, and Slit.
  • Investigation of retinoic acid and lipid signaling in embryogenesis.

Related Experiment Videos

Main Results:

  • Identification of genes involved in crucial embryonic signaling pathways.
  • Detailed analysis revealed the intricate genetic network controlling embryonic patterning.
  • Novel insights into the regulation of BMP, Nodal, Wnt, FGF, Hedgehog, Delta, Slit, retinoic acid, and lipid signaling.

Conclusions:

  • The study provides a comprehensive understanding of the genetic underpinnings of zebrafish embryogenesis.
  • The identified genetic network highlights the complex interplay of signaling pathways in pattern formation.
  • This research offers a foundation for future studies on developmental gene function and regulation.