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Semi-automated update and cleanup of structural RNA alignment databases

J Gorodkin1, C Zwieb, B Knudsen

  • 1Department of Ecology and Genetics, The Institute of Biological Sciences, University of Aarhus, Building 540, Ny Munkegade, DK-8000 Aarhus C, Denmark.

Bioinformatics (Oxford, England)
|July 13, 2001
PubMed
Abstract

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...