Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional ventilation-perfusion relationships.

R H Secker-Walker, P O Alderson, J Wilhelm

    Respiration; International Review of Thoracic Diseases
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dynamics of multisystem inflammatory syndrome in children associated to COVID-19 in Chile: Epidemiologic trends during pandemic, before and after children vaccination.

    Vaccine·2024
    Same author

    All-optical subcycle microscopy on atomic length scales.

    Nature·2024
    Same author

    Tunable non-integer high-harmonic generation in a topological insulator.

    Nature·2021
    Same author

    Strange Electromagnetic Form Factors of the Nucleon with N_{f}=2+1 O(a)-Improved Wilson Fermions.

    Physical review letters·2019
    Same author

    A novel stacked generalization of models for improved TB detection in chest radiographs.

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2018
    Same author

    Proteomic analysis of peroxynitrite-induced protein nitration in isolated beef heart mitochondria.

    Physiological research·2018
    Same journal

    Residual AHI Measurement from PAP Devices Versus Home Polygraphy: A Method Comparison Study Using Real World Data.

    Respiration; international review of thoracic diseases·2026
    Same journal

    Unveiling Sex Differences in Severe Acute COPD Exacerbations requiring ICU admission: Evidence from a French Cohort.

    Respiration; international review of thoracic diseases·2026
    Same journal

    Intrapleural Fibrinolytics use in Children with Pleural Empyema: Safe and Effective.

    Respiration; international review of thoracic diseases·2026
    Same journal

    Learning Curve for Transbronchial Lung Cryobiopsy in Interstitial Lung Disease Diagnosis: A Multicenter Experience.

    Respiration; international review of thoracic diseases·2026
    Same journal

    Follow-Up Care After Adult Lung Transplantation: Summary of an Evidence-Based Clinical Practice Guideline for German-Speaking Countries.

    Respiration; international review of thoracic diseases·2026
    Same journal

    Real-world Sotatercept Eligibility: Analysis from the FOCUS-PAH Registry.

    Respiration; international review of thoracic diseases·2026
    See all related articles

    This study compared two methods for assessing regional ventilation-perfusion ratios in healthy individuals and patients with pulmonary embolism or chronic obstructive pulmonary disease (COPD). The fractional exchange method effectively distinguished COPD patients from other groups.

    Area of Science:

    • Pulmonary Medicine
    • Medical Imaging
    • Respiratory Physiology

    Background:

    • Regional ventilation-perfusion (V/Q) ratios are crucial for assessing lung function.
    • Accurate V/Q measurement aids in diagnosing respiratory diseases.
    • Existing methods may have limitations in differentiating specific lung conditions.

    Purpose of the Study:

    • To compare two distinct methods for determining regional V/Q ratios.
    • To evaluate the efficacy of these methods in distinguishing between healthy subjects, pulmonary embolism (PE) patients, and chronic obstructive pulmonary disease (COPD) patients.
    • To identify the most effective method for diagnosing COPD based on V/Q distribution.

    Main Methods:

    • Regional V/Q ratios were assessed in 12 healthy subjects, 16 PE patients, and 22 COPD patients.

    Related Experiment Videos

  • Xenon-133 ventilation studies and 99mTc-labeled particle perfusion scans were utilized.
  • Two calculation approaches were employed: fractional air exchange and relative tidal volume distribution.

    • Main Results:

    • Both methods yielded comparable V/Q distribution patterns in healthy subjects and PE patients.
    • The fractional air exchange method demonstrated a clear distinction between COPD patients and the other groups.
    • This suggests differential V/Q abnormalities specific to COPD.

    Conclusions:

    • The fractional air exchange method is superior for differentiating COPD patients based on regional V/Q ratios.
    • This finding has implications for improved diagnostic accuracy in respiratory medicine.
    • Further research can explore the clinical utility of this method in V/Q imaging.