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[Induction by ethanol of 'phenomenon of switching estrogen effect' and its correction]
L M Bershteĭn1, E V Tsyrlina, T E Poroshina
1Petrov Research Institute of Oncology, 189646, St. Petersburg, Pesochny-2, Russia.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|July 14, 2001
Abstract:
Drinking of 5% ethanol in combination with estradiol induced genotoxic (G) changes in the rat uterine tissue. The changes could be prevented by N-acetylcysteine or melatonin. The data obtained suggest that ascorbic acid and alpha-tocopherol may be recommended in combination with N-acetylcysteine for repair of estrogen effect switching phenomenon.