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Updated: Aug 14, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

[Toxic effects of baclofen in a patient with chronic renal insufficiency]

M Kroczak1, A Rakus

  • 1I Oddziału Chorób Wewnetrznych o Profilu Nefrologicznym z Ośrodkiem Dializ ul. Armii Krajowej 7, 98-200 Sieradz.

Przeglad Lekarski
|July 14, 2001
PubMed

In this work the authors reported the case of a 29-year-old woman, who had been dialysed since 1997 in the course of chronic pyelonephritis caused by vesicoureteral reflux. Due to the detrusor vesica urinariay's hypofunction (confirmed by repeated urodynamic studies) the patient was prescribed Baclofen with a dosage of 2 x 10 mg per 24 hours. In the course of Baclofen's therapy, toxic effects of the drug like weakness, nausea, vomiting and fears appeared during the second day of treatment. They had been increasing since the patient's admission to the Dialysis Centre where she had immediately undergone the planned haemodialysis. After the initial increase of the poisoning symptoms including the loss of consciousness, patient's state of health improved after approximately two hours since the haemodialysis had been performed. After five more days in hospital, the patient was discharged in general good condition (two more planned haemodialyses were performed at the time of treatment).

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