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[Affinity chromatography of nucleoprotein complexes]
I Iu Riadnova1, I A Chernova, L K Shataeva
1St. Petersburg Institute of Bioregulation and Gerontology, North-Western Department of the Russian Academy of Medical Sciences, 197110, Russia, St. Peterburg.
Voprosy Meditsinskoi Khimii
|July 14, 2001
Abstract:
Affinity sorbent containing cellular membranes of the cerebral cortex was obtained by means of an inclusion into porous matrix of polyacrylonitrile. Sorption of model and natural nucleoprotein complexes on the obtained sorbent was studied by the method of affinity chromatography. Distribution coefficients were determined. Natural nucleoprotein complexes isolated from brain possess a greater selectivity of binding to the cellular membranes of the cerebral cortex than that from liver.