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Water as a source of errors in reference materials.

S Rückold1, K H Grobecker, H D Isengard

  • 1European Commission-Joint Research Centre-Institute for Reference Materials and Measurements, Geel, Belgium.

Fresenius' Journal of Analytical Chemistry
|July 14, 2001
PubMed
Summary

Intensive drying can degrade biological reference materials. Optimizing water content and activity is crucial for stability, accurate measurements, and easier handling.

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Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Long-term stability of reference materials is critical, especially for biological matrices.
  • Deterioration during shelf-life must be prevented.
  • The impact of intensive drying on reference materials has been underestimated.

Purpose of the Study:

  • To investigate mechanisms of deterioration in reference materials related to water activity and content.
  • To evaluate the influence of drying methods on reference material stability.
  • To determine optimal water content and activity ranges for biological matrices.

Main Methods:

  • Analysis of water and moisture content in six reference materials.
  • Determination of water sorption isotherms.
  • Comparison of different dry mass correction methods.

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Main Results:

  • Drying methods significantly impact reference material stability and certified values.
  • Accurate dry mass corrections are essential for reliable certified contents.
  • Optimal ranges for water activity and content minimize hygroscopicity and deterioration in biological matrices.

Conclusions:

  • Intensive drying can cause underappreciated deterioration in biological reference materials.
  • Selecting appropriate dry mass correction methods is vital for accurate certification.
  • Defined water content and activity ranges enhance biological reference material stability and usability.