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Updated: Oct 5, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxacin
J L Vílchez1, L Araujo, A Prieto
1Department of Analytical Chemistry, Faculty of Sciences, University of Granada, C/. Fuentenueva s/n, E-18071 Granada, Spain.
Abstract:
A differential-pulse adsorptive stripping voltammetric method for the determination of trace amounts of the antibacterial lomefloxacin is proposed. By using an accumulation potential of -0.30 V and a 2 min accumulation time, the linear concentration range of application was 1.0-10.0 ng ml(-1) of lomefloxacin, with a relative standard deviation of 3.8% (for a level of 5.0 ng ml(-1)) and a detection limit of 0.3 ng ml(-1). The method was applied to determination of lomefloxacin in human urine and serum samples. It was validated using HPLC as a reference method. Recovery levels of the method reached 100% in all cases.
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