Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gender difference in age-related changes in vascular function.

K Jensen-Urstad1, J Johansson

  • 1Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden. kerstinju@telia.com

Journal of Internal Medicine
|July 17, 2001
PubMed
Summary

In 55-year-olds, conventional cardiovascular risk factors do not correlate with flow-mediated dilation (FMD), a measure of vascular function. However, FMD decreases in women by age 55, potentially due to hormonal changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing Systemic Risk Assessment for Complex, Interdependent Systems: A Research Agenda.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same author

Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial.

Critical care (London, England)·2024
Same author

Oncological outcomes of standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer in the multicentre, randomised, controlled NeoRes II trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007-2015.

The journal of nutrition, health & aging·2023
Same author

Burden of in-hospital care in oesophageal cancer: national population-based study.

BJS open·2021
Same author

Impact of surgical resection rate on survival in gastric cancer: nationwide study.

BJS open·2021

Area of Science:

  • Cardiovascular Science
  • Vascular Biology
  • Gerontology

Background:

  • Cardiovascular disease risk factors increase with age.
  • Vascular function, assessed by brachial artery dilatation, is crucial for cardiovascular health.
  • Understanding age-related changes in vascular function and risk factors is vital for preventative strategies.

Purpose of the Study:

  • To investigate the relationship between vascular function (endothelium-dependent and independent) and cardiovascular risk factors in 55-year-old men and women.
  • To compare vascular function and risk factor prevalence in 55-year-olds with a younger population (35-year-olds).

Main Methods:

  • Vascular function measured using flow-mediated dilatation (FMD) and nitroglycerine (NTG)-mediated dilatation of the brachial artery via ultrasound.

Related Experiment Videos

  • Participants included 55-year-old men and women, compared to a previously studied 35-year-old cohort.
  • Conventional cardiovascular risk factors (gender, smoking, lipids, blood pressure) were assessed.

    • Main Results:

    • Flow-mediated dilatation (FMD) was similar in 55-year-old men and women and did not correlate with conventional cardiovascular risk factors.
    • Nitroglycerine-mediated dilatation correlated with body mass index (BMI) in men and a risk factor score in women.
    • A higher prevalence of cardiovascular risk factors was observed in 55-year-olds compared to 35-year-olds.
    • FMD was reduced in 55-year-old women compared to 35-year-old women, while FMD remained similar in men across age groups.

    Conclusions:

    • Conventional cardiovascular risk factors are not associated with FMD in 55-year-olds, despite a high prevalence of these factors.
    • Reduced FMD in 55-year-old women compared to younger women may be linked to postmenopausal hormonal changes.
    • Nitroglycerine-mediated dilatation shows some correlation with BMI and risk factor scores, indicating preserved non-endothelial-dependent function.