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Discovery and SAR of org 24598-a selective glycine uptake inhibitor
1Department of Medicinal Chemistry, Organon Research and Development Group, Newhouse, Lanarkshire ML1 5SH, Scotland, UK.
Bioorganic & Medicinal Chemistry Letters
|July 17, 2001
Abstract:
The discovery of Org 24598, one of the first potent and selective inhibitors of the glycine transporter is discussed. In vitro structure-activity relationships (SARs) data for interaction of a ligand with this system is discussed.