TTP, a C3H zinc finger protein gene, is expressed in mouse ovarian oocytes

G te Kronnie1, J Samallo, H Schipper

  • 1Wageningen Institute of Animal Sciences (WIAS), Experimental Zoology Group, Agricultural University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands.

The gene TTP, encoding a C3H zinc finger protein of the TIS11 family, is expressed in growing mouse oocytes. The gene is downregulated in Graafian follicles shortly before ovulation. This corresponds to a possible function in regulation of maternal mRNA translation, a function attributed to related C3H class genes in Caenorhabditis elegans, zebrafish, and Xenopus.