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New hemisynthetic manoyl oxide derivatives with antimicrobial activity
E Kalpoutzakis1, N Aligiannis, S Mitaku
1Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, Greece.
Chemical & Pharmaceutical Bulletin
|July 18, 2001
Abstract:
The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-beta-hydroxy-13-epi-manoyl oxide (ribenol) is reported. The chloroethyl carbamidic ester 9 showed the strongest antimicrobial activity against all the tested gram (+), gram (-) bacteria and pathogenic fungi. Moreover, the glycoside 11 exhibited an interesting activity against the three tested fungi.