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Updated: Oct 5, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and

H Vacher1, R Romi-Lebrun, C Mourre

  • 1UMR 6560 CNRSUniversité de la Mediterranée, Faculté de Médecine Nord, Marseille, France.

FEBS Letters
|July 18, 2001
PubMed

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...